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Home - Products - JAK/STAT Signaling - STAT - FLLL-31

FLLL-31

CAS No. 52328-97-9

FLLL-31 ( FLLL31;Tetramethylcurcumin )

Catalog No. M14849 CAS No. 52328-97-9

FLLL-31 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FLLL-31
  • Note
    Research use only, not for human use.
  • Brief Description
    FLLL-31 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells.
  • Description
    FLLL-31 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells; induces apoptosis in pancreatic and breast cancer cell lines; also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells; decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines; also exhibits anti-inflammatory effects on macrophage activation, lymphocyte differentiation, and pro-inflammatory factor production.
  • Synonyms
    FLLL31;Tetramethylcurcumin
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    52328-97-9
  • Formula Weight
    424.49
  • Molecular Formula
    C25H28O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C(C)(C)C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)/C=C/C2=CC=C(OC)C(OC)=C2
  • Chemical Name
    (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lin L, et al. Cancer Res. 2010 Mar 15;70(6):2445-54.
2. Yuan S, et al. Int Immunopharmacol. 2014 Jul;21(1):128-36.
3. Holmer R, et al. BMC Cancer. 2015 Dec 16;15:975.
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