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FGI-104

CAS No. ——

FGI-104( FGI104 )

Catalog No. M17090 CAS No. ——

FGI-104 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FGI-104
  • Note
    Research use only, not for human use.
  • Brief Description
    FGI-104 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67).
  • Description
    FGI-104 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67); protects mice against a lethal challenge with a mouse-adapted strain of either ZEBOV or MARV-Ravn as a single intraperitoneal dose of 10 mg/kg; reduces viremia and the viral burden in kidney, liver, and spleen tissues in a murine model of ZEBOV infection.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    FGI104
  • Pathway
    Microbiology/Virology
  • Target
    Filovirus
  • Recptor
    Filovirus
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    492.016
  • Molecular Formula
    C28H30ClN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)-6-[4-(hydroxymethyl)-3-methoxyphenyl]phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Warren TK, et al. Antimicrob Agents Chemother. 2010 May;54(5):2152-9. 2. Haque A, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):5892-902. 3. De Clercq E. Med Res Rev. 2013 Nov;33(6):1249-77.
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