FCCP( Trifluoromethoxy carbonylcyanide phenylhydrazone )

Catalog No. M14275 CAS No. 370-86-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

FCCP
Note

Research use only, not for human use.
Brief Description

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.
Description

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.(In Vitro):FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability in K695sw cells. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation.
In Vitro

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In Vivo

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Synonyms

Trifluoromethoxy carbonylcyanide phenylhydrazone
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Cancer
Indication

——

CAS Number

370-86-5
Formula Weight

254.17
Molecular Formula

C10H5F3N4O
Purity

>98% (HPLC)
Solubility

Ethanol: 50 mg/mL (196.71 mM) DMSO: 50 mg/mL (196.71 mM) Water: <1 mg/mL
SMILES

N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1
Chemical Name

N-(4-(trifluoromethoxy)phenyl)carbonohydrazonoyl dicyanide

1.HEYTLER PG et al. A new class of uncoupling agents--carbonyl cyanide phenylhydrazones. Biochem Biophys Res Commun. 1962 May 4;7:272-5.

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