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IMR-1A

CAS No. 331862-41-0

IMR-1A ( IMR-1A; IMR 1A; Inhibitor of Mastermind Recruitment-1 Acid )

Catalog No. M17483 CAS No. 331862-41-0

IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 222 In Stock
10MG 332 In Stock
25MG 560 In Stock
50MG 797 In Stock
100MG 1071 In Stock
500MG 2187 In Stock
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Biological Information

  • Product Name
    IMR-1A
  • Note
    Research use only, not for human use.
  • Brief Description
    IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
  • Description
    IMR-1A is a metabolite of IMR-1. IMR-1A acts as Notch inhibitor and targeting gene transcription by disrupting Mam1 recruitment to chromatin.
  • Synonyms
    IMR-1A; IMR 1A; Inhibitor of Mastermind Recruitment-1 Acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Notch
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    331862-41-0
  • Formula Weight
    325.36
  • Molecular Formula
    C13H11NO5S2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 31 mg/mL; 95.28 mM
  • SMILES
    O=C(O)COc1ccc(/C=C/2\SC(=S)NC2=O)cc1OC
  • Chemical Name
    2-[2-Methoxy-4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Astudillo L,et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.
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