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IMR-1A
CAS No. 331862-41-0
IMR-1A ( IMR-1A; IMR 1A; Inhibitor of Mastermind Recruitment-1 Acid )
Catalog No. M17483 CAS No. 331862-41-0
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | In Stock |
|
| 10MG | 332 | In Stock |
|
| 25MG | 560 | In Stock |
|
| 50MG | 797 | In Stock |
|
| 100MG | 1071 | In Stock |
|
| 500MG | 2187 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIMR-1A
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NoteResearch use only, not for human use.
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Brief DescriptionIMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
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DescriptionIMR-1A is a metabolite of IMR-1. IMR-1A acts as Notch inhibitor and targeting gene transcription by disrupting Mam1 recruitment to chromatin.
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SynonymsIMR-1A; IMR 1A; Inhibitor of Mastermind Recruitment-1 Acid
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PathwayOthers
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TargetOther Targets
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RecptorNotch
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number331862-41-0
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Formula Weight325.36
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Molecular FormulaC13H11NO5S2
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Purity98%
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SolubilityDMSO : ≥ 31 mg/mL; 95.28 mM
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SMILESO=C(O)COc1ccc(/C=C/2\SC(=S)NC2=O)cc1OC
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Chemical Name2-[2-Methoxy-4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Astudillo L,et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.
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