IMR-1A ( IMR-1A; IMR 1A; Inhibitor of Mastermind Recruitment-1 Acid )

Catalog No. M17483 CAS No. 331862-41-0

IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.

Purity : 98%

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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5MG	222	In Stock
10MG	332	In Stock
25MG	560	In Stock
50MG	797	In Stock
100MG	1071	In Stock
500MG	2187	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

IMR-1A
Note

Research use only, not for human use.
Brief Description

IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
Description

IMR-1A is a metabolite of IMR-1. IMR-1A acts as Notch inhibitor and targeting gene transcription by disrupting Mam1 recruitment to chromatin.
Synonyms

IMR-1A; IMR 1A; Inhibitor of Mastermind Recruitment-1 Acid
Pathway

Others
Target

Other Targets
Recptor

Notch
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

331862-41-0
Formula Weight

325.36
Molecular Formula

C13H11NO5S2
Purity

98%
Solubility

DMSO : ≥ 31 mg/mL; 95.28 mM
SMILES

O=C(O)COc1ccc(/C=C/2\SC(=S)NC2=O)cc1OC
Chemical Name

2-[2-Methoxy-4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Astudillo L,et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.

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