
F-15599
CAS No. 635323-95-4
F-15599( —— )
Catalog No. M20693 CAS No. 635323-95-4
F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 123 | In Stock |
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5MG | 215 | In Stock |
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10MG | 345 | In Stock |
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25MG | 582 | In Stock |
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50MG | 830 | In Stock |
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100MG | 1125 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameF-15599
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NoteResearch use only, not for human use.
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Brief DescriptionF-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).
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DescriptionF-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).
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In Vitro——
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In VivoF15599 (0.06 or 0.12 mg/kg) significantly reduces l-DOPA-induced dyskinesia (LID), without affecting motor performance of rats. Rats treated with F15599 manifest less LID and mild 5-HT syndrome with the high dose of 30 μg/μL. F15599 (0.0625, 0.125, 0.25, 0.5 and 1.0 mg/kg, i,p,) results in a significant and dose-dependent (MED?=?0.125 mg/kg) delay in the latency to attack, and a potent reduction (ID50?=?0.095 mg/kg) in the amount of aggressive behaviour directed towards the intruder rat. Starting from the 0.25 mg/kg dose, F15599 induces clear signs of the so-called serotonin syndrome characterized by flat body posture, head-waving, lower lip retraction and hindlimb abduction, leading to increased behavioural inactivity scores and social disengagement. F15599 increases the discharge rate of pyramidal neurones in medial prefrontal cortex (mPFC) from 0.2 μg/kg i.v and reduces that of dorsal raphe 5-hydroxytryptaminergic neurones at doses >10-fold higher (minimal effective dose 8.2 μg/kg i.v.). F15599 increases dopamine output in mPFC (an effect dependent on the activation of postsynaptic 5-HT1A receptors) with an ED50 of 30 μg/kg i.p., whereas it reduces hippocampal 5-HT release (an effect dependent exclusively on 5-HT1A autoreceptor activation) with an ED50 of 240 μg/kg i.p.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT1A
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Research Area——
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Indication——
Chemical Information
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CAS Number635323-95-4
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Formula Weight394.85
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Molecular FormulaC19H21ClF2N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (633.15 mM)
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SMILESCc1cnc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
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Chemical Name(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyrimidin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.De Boer S F Newman-Tancredi A . Anti-aggressive effects of the selective high-efficacy ‘biased’ 5-HT1Areceptor agonists F15599 and F13714 in male WTG rats[J]. Psychopharmacology 2016 233(6):937-947.
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