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Evofosfamide
CAS No. 918633-87-1
Evofosfamide ( TH302;TH 302;TH-302 )
Catalog No. M16596 CAS No. 918633-87-1
A potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 64 | In Stock |
|
| 5MG | 104 | In Stock |
|
| 10MG | 142 | In Stock |
|
| 25MG | 248 | In Stock |
|
| 50MG | 397 | In Stock |
|
| 100MG | 612 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEvofosfamide
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes.
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DescriptionA potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes; inhibits H246 cells and HT29 cells with IC50 of 0.1 uM and 0.2 uM respectively; active in an in vivo MIA PaCa-2 pancreatic cancer orthotopic xenograft model.Pancreatic Cancer,Phase 3 Clinical
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SynonymsTH302;TH 302;TH-302
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PathwayCell Cycle/DNA Damage
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TargetDNA Alkylator
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RecptorHypoxia-activatedprodrug
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Research AreaCancer
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IndicationPancreatic Cancer
Chemical Information
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CAS Number918633-87-1
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Formula Weight449.04
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Molecular FormulaC9H16Br2N5O4P
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Purity>98% (HPLC)
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SolubilityDMSO; H2O: 0.14 mg/mL
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SMILESO=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C
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Chemical NamePhosphorodiamidic acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Duan JX, et al. J Med Chem. 2008 Apr 24;51(8):2412-20.
2. Hu J, et al. Blood. 2010 Sep 2;116(9):1524-7.
3. Meng F, et al. Mol Cancer Ther. 2012 Mar;11(3):740-51.
2. Hu J, et al. Blood. 2010 Sep 2;116(9):1524-7.
3. Meng F, et al. Mol Cancer Ther. 2012 Mar;11(3):740-51.
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