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Evofosfamide

CAS No. 918633-87-1

Evofosfamide ( TH302;TH 302;TH-302 )

Catalog No. M16596 CAS No. 918633-87-1

A potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 104 In Stock
10MG 142 In Stock
25MG 248 In Stock
50MG 397 In Stock
100MG 612 In Stock
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Biological Information

  • Product Name
    Evofosfamide
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes.
  • Description
    A potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes; inhibits H246 cells and HT29 cells with IC50 of 0.1 uM and 0.2 uM respectively; active in an in vivo MIA PaCa-2 pancreatic cancer orthotopic xenograft model.Pancreatic Cancer,Phase 3 Clinical
  • Synonyms
    TH302;TH 302;TH-302
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    Hypoxia-activatedprodrug
  • Research Area
    Cancer
  • Indication
    Pancreatic Cancer

Chemical Information

  • CAS Number
    918633-87-1
  • Formula Weight
    449.04
  • Molecular Formula
    C9H16Br2N5O4P
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO; H2O: 0.14 mg/mL
  • SMILES
    O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C
  • Chemical Name
    Phosphorodiamidic acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Duan JX, et al. J Med Chem. 2008 Apr 24;51(8):2412-20.
2. Hu J, et al. Blood. 2010 Sep 2;116(9):1524-7.
3. Meng F, et al. Mol Cancer Ther. 2012 Mar;11(3):740-51.
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