CM03 ( G-quadruplex binder CM03 )

Catalog No. M13332 CAS No. 2101208-44-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

CM03
Note

Research use only, not for human use.
Brief Description

CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM).
Description

CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM); CM03 shows >20-fold selectivity for MIA PaCa-2 compared to MCF-7 cells, also shows greater selectivity than MM41 relative to the non-oncogenic control fibroblasts; demonstrates anticancer activity in PDAC models, with a superior profile compared to gemcitabine.
Synonyms

G-quadruplex binder CM03
Pathway

Cell Cycle/DNA Damage
Target

DNA Alkylator
Recptor

DNA Alkylator
Research Area

——
Indication

——

CAS Number

2101208-44-8
Formula Weight

632.76
Molecular Formula

C34H44N6O6
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N(CCCN1CCOCC1)C(C2=C3C4=C(C(N5CCCN6CCOCC6)=O)C=C2NCCN7CCCC7)=O)C3=CC=C4C5=O
Chemical Name

2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone

1. Marchetti C, et al. J Med Chem. 2018 Feb 7. doi: 10.1021/acs.jmedchem.7b01781.

Calculator

molnova catalog