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CM03

CAS No. 2101208-44-8

CM03 ( G-quadruplex binder CM03 )

Catalog No. M13332 CAS No. 2101208-44-8

CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CM03
  • Note
    Research use only, not for human use.
  • Brief Description
    CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM).
  • Description
    CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM); CM03 shows >20-fold selectivity for MIA PaCa-2 compared to MCF-7 cells, also shows greater selectivity than MM41 relative to the non-oncogenic control fibroblasts; demonstrates anticancer activity in PDAC models, with a superior profile compared to gemcitabine.
  • Synonyms
    G-quadruplex binder CM03
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    DNA Alkylator
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2101208-44-8
  • Formula Weight
    632.76
  • Molecular Formula
    C34H44N6O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N(CCCN1CCOCC1)C(C2=C3C4=C(C(N5CCCN6CCOCC6)=O)C=C2NCCN7CCCC7)=O)C3=CC=C4C5=O
  • Chemical Name
    2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Marchetti C, et al. J Med Chem. 2018 Feb 7. doi: 10.1021/acs.jmedchem.7b01781.
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