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Evenamide

CAS No. 1092977-61-1

Evenamide( NW-3509 )

Catalog No. M23295 CAS No. 1092977-61-1

Evenamide is a sodium channel blocker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Evenamide
  • Note
    Research use only, not for human use.
  • Brief Description
    Evenamide is a sodium channel blocker.
  • Description
    Evenamide is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.
  • In Vitro
    Evenamide selectively blocks voltage-gated sodium channels (VGSCs) in a voltage-and use-dependent manner (Ki=0.4 μM) and modulates sustained repetitive firing without inducing impairment of the normal neuronal excitability. Evenamide does not bind, inhibit or interact with over 130 receptors, enzymes, or transporters.
  • In Vivo
    Evenamide is active in a wide range of psychiatric animal models in monotherapy and addon to antipsychotics. Evenamide is effective in attenuating the social interaction deficit in Cl 395 (PCP)-impaired rats (MED=1 mg/kg po).
  • Synonyms
    NW-3509
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1092977-61-1
  • Formula Weight
    278.39
  • Molecular Formula
    C16H26N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:290 mg/mL (1041.70 mM; Need ultrasonic)
  • SMILES
    CCCCOc1cccc(CCNCC(N(C)C)=O)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Valentina Zuliani, et al. Advances in Design and Development of Sodium Channel Blockers. Ion Channels and Their Inhibitors pp 79-115.
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