Evenamide( NW-3509 )

Catalog No. M23295 CAS No. 1092977-61-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Evenamide
Note

Research use only, not for human use.
Brief Description

Evenamide is a sodium channel blocker.
Description

Evenamide is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.
In Vitro

Evenamide selectively blocks voltage-gated sodium channels (VGSCs) in a voltage-and use-dependent manner (Ki=0.4 μM) and modulates sustained repetitive firing without inducing impairment of the normal neuronal excitability. Evenamide does not bind, inhibit or interact with over 130 receptors, enzymes, or transporters.
In Vivo

Evenamide is active in a wide range of psychiatric animal models in monotherapy and addon to antipsychotics. Evenamide is effective in attenuating the social interaction deficit in Cl 395 (PCP)-impaired rats (MED=1 mg/kg po).
Synonyms

NW-3509
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Sodium channel
Research Area

——
Indication

——

1.Valentina Zuliani, et al. Advances in Design and Development of Sodium Channel Blockers. Ion Channels and Their Inhibitors pp 79-115.

Calculator

molnova catalog