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Bazedoxifene
CAS No. 198481-32-2
Bazedoxifene ( TSE-424 )
Catalog No. M29641 CAS No. 198481-32-2
Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 89 | In Stock |
|
| 10MG | 138 | In Stock |
|
| 25MG | 268 | In Stock |
|
| 50MG | 398 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameBazedoxifene
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NoteResearch use only, not for human use.
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Brief DescriptionBazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively.
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DescriptionBazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer.Bazedoxifene is a small molecular GP130 inhibitor, which binds to GP130 D1 domain.Bazedoxifene inhibits STAT3 phosphorylation induced by Il-6 and IL-11 in GP130/STAT3 pathway signaling.Bazedoxifene (10 μM-20 μM; 2 hours) inhibits STAT3 Phosphorylation Induced by cytokines in human pancreatic cancer cells.Bazedoxifene (5-20 μM; overnight) induces apoptosis in human pancreatic cancer cells.Bazedoxifene inhibits STAT3 nuclear translocation induced by IL-6.Bazedoxifene blocks the cells migration in pancreatic cancer cells by inhibition of GP130.
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SynonymsTSE-424
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number198481-32-2
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Formula Weight470.6
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Molecular FormulaC30H34N2O3
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (212.49 mM; Need ultrasonic)
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SMILESCC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barry S Komm, et al. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology. 2005 Sep;146(9):3999-4008.
2. Xiaojuan Wu, et al. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Mol Cancer Ther. 2016 Nov; 15(11): 2609–2619.
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