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Espindolol

CAS No. 26328-11-0

Espindolol( AGI-001 | MT-102 | AGI001 | MT102 | AGI 001 | MT 102 )

Catalog No. M27876 CAS No. 26328-11-0

Espindolol is a novel non-selective β blocker with central 5-HT1a and partial β2 receptor agonist effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Espindolol
  • Note
    Research use only, not for human use.
  • Brief Description
    Espindolol is a novel non-selective β blocker with central 5-HT1a and partial β2 receptor agonist effects.
  • Description
    Espindolol is a novel non-selective β blocker with central 5-HT1a and partial β2 receptor agonist effects.(In Vivo):Placebo-treated rats progressively lost body weight (-15.5 ± 7.2 g), lean mass (-1.5 ± 4.2 g), and fat mass (-15.6 ± 2.7 g), while espindolol treatment increased body weight (+8.0 ± 6.1 g, p < 0.05), particularly lean mass (+43.4 ± 3.5 g, p < 0.001), and reduced fat mass further (-38.6 ± 3.4 g, p < 0.001). Anabolic/catabolic signaling was assessed in gastrocnemius muscle. Espindolol decreased proteasome and caspase-3 proteolytic activities by approximately 50 % (all p < 0.05).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague Dawley ratsDosage:15 mg/kg Administration:Intraperitoneal injection; 15 mg/kg, 20 min acute treatment or 24 h, 16 h and 20 min short-term treatment before [3H]-WAY 100635 injection Result:Reduced [3H]-WAY 100635 accumulation in 5-HT1A receptor-containing brain areas, but showed no effect on the dorsal raphe nucleus (DRN), and the CA1 and CA3 hippocampal areas.
  • Synonyms
    AGI-001 | MT-102 | AGI001 | MT102 | AGI 001 | MT 102
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    26328-11-0
  • Formula Weight
    248.326
  • Molecular Formula
    C14H20N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (402.71 mM)
  • SMILES
    CC(C)NC[C@H](O)COc1cccc2[nH]ccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fujimoto Y, et al. Fixed drug eruption due to allylisopropylacetylurea. Contact Dermatitis. 1993 May;28(5):282-4.
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