Espindolol

Research use only, not for human use.

Espindolol is a novel non-selective β blocker with central 5-HT1a and partial β2 receptor agonist effects.

Espindolol is a novel non-selective β blocker with central 5-HT1a and partial β2 receptor agonist effects.(In Vivo):Placebo-treated rats progressively lost body weight (-15.5 ± 7.2 g), lean mass (-1.5 ± 4.2 g), and fat mass (-15.6 ± 2.7 g), while espindolol treatment increased body weight (+8.0 ± 6.1 g, p < 0.05), particularly lean mass (+43.4 ± 3.5 g, p < 0.001), and reduced fat mass further (-38.6 ± 3.4 g, p < 0.001). Anabolic/catabolic signaling was assessed in gastrocnemius muscle. Espindolol decreased proteasome and caspase-3 proteolytic activities by approximately 50 % (all p < 0.05).

AGI-001; MT-102; AGI001; MT102; AGI 001; MT 102

Endocrinology/Hormones

5-HT Receptor

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26328-11-0

248.3

C14H20N2O2

>98% (HPLC)

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CC(C)NC[C@H](O)COc1cccc2[nH]ccc12

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(-20℃)

With Ice Pack

≥ 2 years