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Epolactaene

CAS No. 167782-17-4

Epolactaene( Epolactaene )

Catalog No. M12563 CAS No. 167782-17-4

Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Epolactaene
  • Note
    Research use only, not for human use.
  • Brief Description
    Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells.
  • Description
    Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells; inhibits DNA topoisomerase II (topo II), binds to Hsp60 Cys442 resulting in the inhibition of chaperone activity; also reacts with N-acetylcysteine methyl ester and induces the disulfide formation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Epolactaene
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    167782-17-4
  • Formula Weight
    389.45
  • Molecular Formula
    C21H27NO6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OC)C(/C=C(C)/C=C/CC/C=C(C)/C([C@@]12C(NC(C)(O)[C@]1([H])O2)=O)=O)=C/C
  • Chemical Name
    Methyl (2E,3E,5E,9E)-2-ethylidene-11-[(1R,5R)-4-hydroxy-4-methyl-2-oxo-6-oxa-3-azabicyclo[3.1.0]hexan-1-yl]-4,10-dimethyl-11-oxoundeca-3,5,9-trienoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kakeya H, et al. J Antibiot (Tokyo). 1995 Jul;48(7):733-5. 2. Nagumo Y, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4425-9. 3. Nagumo Y, et al. Biochem J. 2005 May 1;387(Pt 3):835-40.
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