Entacapone ( OR-611 )

Catalog No. M11233 CAS No. 130929-57-6

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Product Name

Entacapone
Note

Research use only, not for human use.
Brief Description

Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease.
Description

Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration of levodopa and a decarboxylase inhibitor.
Synonyms

OR-611
Pathway

Metabolic Enzyme/Protease
Target

Transferase
Recptor

COMT
Research Area

Neurological Disease
Indication

——

CAS Number

130929-57-6
Formula Weight

305.29
Molecular Formula

C14H15N3O5
Purity

>98%(HPLC)
Solubility

Ethanol: 2 mg/mL (6.55 mM); DMSO: 61 mg/mL (199.81 mM)
SMILES

O=C(N(CC)CC)/C(C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1
Chemical Name

(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide

1.De Santi C, et al. Eur J Clin Pharmacol, 1998, 54(3), 215-219.

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