Ensitrelvir ( S-217622 )

Catalog No. M28855 CAS No. 2647530-73-0

Ensitrelvir.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Ensitrelvir
Note

Research use only, not for human use.
Brief Description

Ensitrelvir.
Description

Ensitrelvir.(In Vitro):The EC50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively. In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir shows the EC50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants.(In Vivo):Ensitrelvir inhibits intrapulmonary replication of SARS-CoV-2 in mice in a dose-dependent manner.
Synonyms

S-217622
Pathway

Others
Target

Other Targets
Recptor

COX-2;5-Lipoxygenase
Research Area

——
Indication

——

Chemical Information

CAS Number

2647530-73-0
Formula Weight

531.9
Molecular Formula

C22H17ClF3N9O2
Purity

>98% (HPLC)
Solubility

——
SMILES

Cn1nc(cc(c(/N=C(\NC(N2Cc3nn(C)cn3)=O)/N(Cc(cc(c(F)c3)F)c3F)C2=O)c2)Cl)c2c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101.

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