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Enbezotinib

CAS No. 2359649-81-1

Enbezotinib( —— )

Catalog No. M35628 CAS No. 2359649-81-1

Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 187 Get Quote
5MG 282 Get Quote
10MG 446 Get Quote
25MG 707 Get Quote
50MG 966 Get Quote
100MG 1242 Get Quote
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Biological Information

  • Product Name
    Enbezotinib
  • Note
    Research use only, not for human use.
  • Brief Description
    Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.
  • Description
    Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer.
  • In Vitro
    Enbezotinib (compound 5) (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells.
  • In Vivo
    Enbezotinib (compound 5) (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice.
  • Synonyms
    ——
  • Pathway
    Tyrosine Kinase
  • Target
    c-RET
  • Recptor
    c-RET
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2359649-81-1
  • Formula Weight
    424.43
  • Molecular Formula
    C21H21FN6O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (235.61 mM; Ultrasonic (<80°C)
  • SMILES
    [H][C@]12CCC[C@@]1([H])N1Cc3cc(F)cnc3O[C@@H](C)CNC(=O)c3cnn4cc(O2)c1nc34
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.
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