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LOXO-292

CAS No. 2152628-33-4

LOXO-292( Selpercatinib | LOXO 292 | LOXO292 )

Catalog No. M13437 CAS No. 2152628-33-4

LOXO-292 (Selpercatinib, LOXO 292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with potential antineoplastic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LOXO-292
  • Note
    Research use only, not for human use.
  • Brief Description
    LOXO-292 (Selpercatinib, LOXO 292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with potential antineoplastic activity.
  • Description
    LOXO-292 (Selpercatinib, LOXO 292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with potential antineoplastic activity; displays >100-fold selectivity versus important off-targets; shows anti-tumor activty in the brain and periphery in RET-dependent tumor models in vivo.Lung Cancer Phase 1 Clinical(In Vivo):Selpercatinib (LOXO-292; 10 mg/kg; i.g.; for 0-2 h) has good pharmacokinetics after oral gavage in FVB/NRj mice.
  • In Vitro
    ——
  • In Vivo
    Selpercatinib (LOXO-292; 10 mg/kg; i.g.; for 0-2 h) has good pharmacokinetics after oral gavage in FVB/NRj mice.Pharmacokinetic Parameters of Selpercatinib in FVB/NRj mice.FVB/NRj mice, 10 mg/kg i.g. Animal Model:Male FVB/NRj mice Dosage:10 mg/kg Administration:Oral gavage; for 7.5 min, 15 min, 30 min, 1 h and 2 h (Pharmacokinetic Analysis)Result:Had good pharmacokinetics after oral gavage in FVB/NRj mice.
  • Synonyms
    Selpercatinib | LOXO 292 | LOXO292
  • Pathway
    Tyrosine Kinase
  • Target
    c-RET
  • Recptor
    c-RET
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    2152628-33-4
  • Formula Weight
    525.613
  • Molecular Formula
    C29H31N7O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 8.33 mg/mL 15.85 mM
  • SMILES
    N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OCC(C)(O)C)=CN2N=C1
  • Chemical Name
    6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Subbiah V, et al. Ann Oncol. 2018 Aug 1;29(8):1869-1876. 2.?Cancer Discov. 2018 Aug;8(8):904-905.
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