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Emivirine
CAS No. 149950-60-7
Emivirine( —— )
Catalog No. M34240 CAS No. 149950-60-7
Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor for human immunodeficiency virus type 1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | Get Quote |
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| 5MG | 69 | Get Quote |
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| 10MG | 112 | Get Quote |
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| 25MG | 182 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameEmivirine
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NoteResearch use only, not for human use.
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Brief DescriptionEmivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor for human immunodeficiency virus type 1.
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DescriptionEmivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity.
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In VitroEmivirine (EMV) is also specific for HIV-1 RT and was without effect on HIV-2.Emivirine (EMV) has no obvious toxicity for human healthy cells.:Cell Viability Assay Cell Line:Human bone marrow cells collected from normal healthy volunteers.Concentration:0, 0.1, 1, 10, or 100 μM.Incubation Time:14 days.Result:At concentrations of 0.1 to 10 μM, no effect on cell growth, lactic acid production, mitochondrial DNA synthesis, or mitochondrial structure was seen compared to what occurred with untreated HepG2 cells.
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In VivoTthe approximate lethal oral dose of Emivirine (EMV) for rats was ≥3 g/kg for males and 2.5 g/kg for females.Animal Model:Male Sprague-Dawley rats.Dosage:50 mg/kg.Administration:Gavage.Result:The oral absorption was 68%.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number149950-60-7
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Formula Weight302.37
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Molecular FormulaC17H22N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (330.72 mM; Ultrasonic )
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SMILESC(C1=C(C(C)C)C(=O)NC(=O)N1COCC)C2=CC=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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BNM-III-170 trifluor...
BNM-III-170 TFA salt is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo.
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Helichrysetin
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes.
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L-870810
A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties.
