Embelin

CAS No. 550-24-3

Embelin( Embelic acid | Emberine | NSC-91874 )

Catalog No. M14989 CAS No. 550-24-3

Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 45 In Stock
25MG 77 In Stock
50MG 144 In Stock
100MG 283 In Stock
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Biological Information

  • Product Name
    Embelin
  • Note
    Research use only, not for human use.
  • Brief Description
    Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties.
  • Description
    Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties; specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM); has anti-inflammatory activities in both acute and chronic irritant contact dermatitis in vivo; also inhibits plasminogen activator inhibitor-1 (PAI-1) with IC50 of 1.62 uM.(In Vitro):Embelin (Embelic acid) has a minimal effect on normal prostate epithelial and fibroblast cells with low levels of XIAP.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Embelic acid | Emberine | NSC-91874
  • Pathway
    Apoptosis
  • Target
    IAP
  • Recptor
    5-Lipoxygenase|mPGES-1|XIAP
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    550-24-3
  • Formula Weight
    294.3859
  • Molecular Formula
    C17H26O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCCCCCCCCCCC1=C(C(=O)C=C(C1=O)O)O
  • Chemical Name
    2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Siegel C, et al. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7. 2. Kalyan Kumar G, et al. Eur J Pharmacol. 2011 Jul 15;662(1-3):63-9. 3. Lin Z, et al. Chem Biol. 2013 Feb 21;20(2):253-61.
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