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Embelin
CAS No. 550-24-3
Embelin( Embelic acid | Emberine | NSC-91874 )
Catalog No. M14989 CAS No. 550-24-3
Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 45 | In Stock |
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| 25MG | 77 | In Stock |
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| 50MG | 144 | In Stock |
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| 100MG | 283 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEmbelin
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NoteResearch use only, not for human use.
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Brief DescriptionEmbelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties.
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DescriptionEmbelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties; specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM); has anti-inflammatory activities in both acute and chronic irritant contact dermatitis in vivo; also inhibits plasminogen activator inhibitor-1 (PAI-1) with IC50 of 1.62 uM.(In Vitro):Embelin (Embelic acid) has a minimal effect on normal prostate epithelial and fibroblast cells with low levels of XIAP.
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In Vitro——
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In Vivo——
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SynonymsEmbelic acid | Emberine | NSC-91874
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PathwayApoptosis
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TargetIAP
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Recptor5-Lipoxygenase|mPGES-1|XIAP
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number550-24-3
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Formula Weight294.3859
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Molecular FormulaC17H26O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCCCCCCCCCCCC1=C(C(=O)C=C(C1=O)O)O
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Chemical Name2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Siegel C, et al. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7.
2. Kalyan Kumar G, et al. Eur J Pharmacol. 2011 Jul 15;662(1-3):63-9.
3. Lin Z, et al. Chem Biol. 2013 Feb 21;20(2):253-61.
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