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Eact

CAS No. 461000-66-8

Eact( —— )

Catalog No. M24413 CAS No. 461000-66-8

Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Eact
  • Note
    Research use only, not for human use.
  • Brief Description
    Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.
  • Description
    Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    TMEM16A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    461000-66-8
  • Formula Weight
    428.5
  • Molecular Formula
    C22H24N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (116.69 mM; Need ultrasonic)
  • SMILES
    COCCN(C1=NC(=CS1)C2=CC=CC=C2)C(=O)C3=CC(=C(C(=C3)OC)OC)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liu S, et al. Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br J Pharmacol. 2016 Apr;173(7):1208-18.
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