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Home - Products - MAPK/ERK Signaling - ERK - ERK-IN-4

ERK-IN-4

CAS No. 1049738-54-6

ERK-IN-4( —— )

Catalog No. M34872 CAS No. 1049738-54-6

ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ERK-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.
  • Description
    ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4has little effect on ERK protein phosphorylation by its upstream activator MEK1/2.
  • In Vitro
    Cell Proliferation AssayCell Line:HeLa, A549, or SUM-159 cells Concentration:10 μM, 20 μM, 30 μM, 40 μM, 150 μM for A549, or SUM-159 cells; 25 μM, 50 μM, 75 μM for HeLa cells Incubation Time:10 days Result:Completely inhibited cell proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    ERK
  • Recptor
    ERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1049738-54-6
  • Formula Weight
    328.814
  • Molecular Formula
    C14H17ClN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (76.03 mM; Ultrasonic (<80°C)
  • SMILES
    Cl.O=C1SC(=CC2=CC=C(OCC)C=C2)C(=O)N1CCN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95.?
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