EPZ-030456 ( EPZ 030456;EPZ030456 )

Catalog No. M12764 CAS No. 1808011-23-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

EPZ-030456
Note

Research use only, not for human use.
Brief Description

EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM.
Description

EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM; displays noncompetitive inhibition with respect to SAM and MEKK2 with Ki of 1.2 and 1.1 nM, respectively; has cellular potency (IC50=48 nM) suitable to probe the in vitro biology of SMYD3 inhibition.
Synonyms

EPZ 030456;EPZ030456
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

1808011-23-5
Formula Weight

572.12
Molecular Formula

C28H34ClN5O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC2=C(NC(C2)=O)C=C1Cl)N[C@H]3C[C@@](N4S(=O)(N5CCC(NCC6=CC=CC=C6)CC5)=O)([H])CC[C@@]4([H])C3
Chemical Name

N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-chloro-2-oxoindoline-5-carboxamide

1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.

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