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Home - Products - Chromatin/Epigenetic - HMTase - EPZ-030456

EPZ-030456

CAS No. 1808011-23-5

EPZ-030456( EPZ 030456 | EPZ030456 )

Catalog No. M12764 CAS No. 1808011-23-5

EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    EPZ-030456
  • Note
    Research use only, not for human use.
  • Brief Description
    EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM.
  • Description
    EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM; displays noncompetitive inhibition with respect to SAM and MEKK2 with Ki of 1.2 and 1.1 nM, respectively; has cellular potency (IC50=48 nM) suitable to probe the in vitro biology of SMYD3 inhibition.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    EPZ 030456 | EPZ030456
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1808011-23-5
  • Formula Weight
    572.121
  • Molecular Formula
    C28H34ClN5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC2=C(NC(C2)=O)C=C1Cl)N[C@H]3C[C@@](N4S(=O)(N5CCC(NCC6=CC=CC=C6)CC5)=O)([H])CC[C@@]4([H])C3
  • Chemical Name
    N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-chloro-2-oxoindoline-5-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.
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