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EED226
CAS No. 2083627-02-3
EED226 ( EED226; EED-226; EED 226 )
Catalog No. M17425 CAS No. 2083627-02-3
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
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| 5MG | 43 | In Stock |
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| 10MG | 68 | In Stock |
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| 25MG | 113 | In Stock |
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| 50MG | 186 | In Stock |
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| 100MG | 332 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEED226
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NoteResearch use only, not for human use.
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Brief DescriptionEED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
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DescriptionEED226 is a potent, selective, and orally bioavailable EED inhibitor. induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model. EED226 induces a conformational change upon binding EED, leading to loss of PRC2 activity. EED226 shows similar activity to SAM-competitive inhibitors in blocking H3K27 methylation of PRC2 target genes and inducing regression of human lymphoma xenograft tumors. Interestingly, EED226 also effectively inhibits PRC2 containing a mutant EZH2 protein resistant to SAM-competitive inhibitors. EED226 inhibits PRC2 activity via an allosteric mechanism and offers an opportunity for treatment of PRC2-dependent cancers. demonstrated very impressive antitumor activities in mouse xenograft model.
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SynonymsEED226; EED-226; EED 226
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PathwayOthers
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TargetOther Targets
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RecptorEED; PRC2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2083627-02-3
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Formula Weight369.4
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Molecular FormulaC17H15N5O3S
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Purity98%
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SolubilityDMSO : ≥ 29 mg/mL. 78.51 mM; H2O : < 0.1 mg/mL
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SMILESc1(n2c(c(cn1)c1ccc(cc1)S(=O)(=O)C)nnc2)NCc1occc1
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Chemical NameN-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)[1,2,4]-triazolo[4,3-c]pyrimidin-5-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Acetylcholine bromid...
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magnolin
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