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EBE-A22
CAS No. 229476-53-3
EBE-A22( EBE-A22 | EBE A22 | EBEA22 )
Catalog No. M17448 CAS No. 229476-53-3
EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
|
| 5MG | 76 | In Stock |
|
| 10MG | 106 | In Stock |
|
| 25MG | 215 | In Stock |
|
| 50MG | 327 | In Stock |
|
| 100MG | 492 | In Stock |
|
| 500MG | 1053 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEBE-A22
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NoteResearch use only, not for human use.
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Brief DescriptionEBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.
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DescriptionEBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE-A22, but not PD153035, interacts preferentially with GC-rich sequences and discriminates against homooligomeric runs of A and T which are often cut more readily by the enzyme in the presence of the drug compared to the control.
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In Vitro——
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In Vivo——
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SynonymsEBE-A22 | EBE A22 | EBEA22
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PathwayAngiogenesis
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TargetFGFR
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RecptorEGFR/ErbB1
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number229476-53-3
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Formula Weight374.23
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Molecular FormulaC17H16BrN3O2
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL 133.61 mM; H2O : < 0.1 mg/mL
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SMILESCN(c1cc(ccc1)Br)c1ncnc2cc(c(cc12)OC)OC
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Chemical NameN-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Goossens JF, et al. DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue. Biochemistry. 2001 Apr 17;40(15):4663-71.
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