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Dronedarone

CAS No. 141626-36-0

Dronedarone ( SR-33589 )

Catalog No. M11734 CAS No. 141626-36-0

A multichannel blocker agent that has antiarrhythmic activity; reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dronedarone
  • Note
    Research use only, not for human use.
  • Brief Description
    A multichannel blocker agent that has antiarrhythmic activity; reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats.
  • Description
    A multichannel blocker agent that has antiarrhythmic activity; reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats; reduces significantly the incidence of ventricular fibrillation (VF) in rats; mainly used for treatment of cardiac arrhythmias.Heart Arrhythmia Approved
  • Synonyms
    SR-33589
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel;Sodium channel;Calcium channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    141626-36-0
  • Formula Weight
    556.76
  • Molecular Formula
    C31H44N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CS(=O)(NC1=CC2=C(OC(CCCC)=C2C(C3=CC=C(OCCCN(CCCC)CCCC)C=C3)=O)C=C1)=O
  • Chemical Name
    Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Aimond F, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):415-24.
2. Sun W, et al. Circulation. 1999 Nov 30;100(22):2276-81.
3. Manakshe G, et al. Indian Heart J. 2012 Mar-Apr;64(2):182-6.
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