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Hexachlorophene

CAS No. 70-30-4

Hexachlorophene ( Nabac; NSC 9887; NSC 49115 )

Catalog No. M15701 CAS No. 70-30-4

Hexachlorophene(Hexachlorofen) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; also is an inhibitor of Wnt/beta-catenin signaling.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hexachlorophene
  • Note
    Research use only, not for human use.
  • Brief Description
    Hexachlorophene(Hexachlorofen) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; also is an inhibitor of Wnt/beta-catenin signaling.
  • Description
    Hexachlorophene(Hexachlorofen) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; also is an inhibitor of Wnt/beta-catenin signaling.
  • Synonyms
    Nabac; NSC 9887; NSC 49115
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    D-LDH; GluDH; SDH
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    70-30-4
  • Formula Weight
    406.90
  • Molecular Formula
    C13H6Cl6O2
  • Purity
    >98%(HPLC)
  • Solubility
    Soluble in water
  • SMILES
    C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
  • Chemical Name
    3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zheng Y, et al. Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. PLoS One. 2012;7(12):e51820.
2. Park S, et al. Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Mol Pharmacol. 2006 Sep;70(3):960-6.
3. Heath RJ, et al. Inhibition of the Staphylococcus aureus naDPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. J Biol Chem. 2000 Feb 18;275(7):4654-9.
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