Drinabant ( AVE-1625 )

Catalog No. M27478 CAS No. 358970-97-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Drinabant
Note

Research use only, not for human use.
Brief Description

Drinabant is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.
Description

Drinabant is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.(In Vivo):Drinabant (10 mg/kg orally once daily), combined with Olanzapine attenuates body weight gain, diminishing the enhanced food intake while maintaining increased energy expenditure and decreased motility. Drinabant (1, 3, and 10 mg/kg ip), reverses abnormally persistent LI induced by MK-801 or neonatal nitric oxide synthase inhibition in rodents, and improves both working and episodic memory.
Synonyms

AVE-1625
Pathway

GPCR/G Protein
Target

Cannabinoid Receptor
Recptor

TRPV1
Research Area

——
Indication

——

CAS Number

358970-97-5
Formula Weight

497.4
Molecular Formula

C23H20Cl2F2N2O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

CS(N(C(C1)CN1C(c(cc1)ccc1Cl)c(cc1)ccc1Cl)c1cc(F)cc(F)c1)(=O)=OCS(N(C(C1)CN1C(c(cc1)ccc1Cl)c(cc1)ccc1Cl)c1cc(F)cc(F)c1)(=O)=O
Chemical Name

——

1.Kym PR, Kort ME, Hutchins CW. Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6.

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