Doxazosin
CAS No. 74191-85-8
Doxazosin ( UK 33274 )
Catalog No. M27548 CAS No. 74191-85-8
Doxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 36 | In Stock |
|
10MG | 51 | In Stock |
|
25MG | 85 | In Stock |
|
50MG | 124 | In Stock |
|
100MG | 188 | In Stock |
|
200MG | 293 | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDoxazosin
-
NoteResearch use only, not for human use.
-
Brief DescriptionDoxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms.
-
DescriptionDoxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms.(In Vitro):Doxazosin, at concentrations of 5-20 mumol/L, increased LDL binding to hepatic cells in a dose-related manner. Also, in these hepatic cells, doxazosin produced dose-related decreases in both newly synthesized cholesterol and cholesterol ester. In rabbit fibroblasts that were LDL receptor negative, de novo cholesterol synthesis was markedly reduced by increasing concentrations of doxazosin. Taken together, these results suggest that doxazosin may have a direct inhibitory effect on cholesterol synthesis independent of the LDL receptor.(In Vivo):Both the enantiomers were highly bound to the plasma proteins of rats, dogs and humans [(-)doxazosin: 89.4%-94.3%; (+)doxazosin: 90.9%-95.4%]. (+)Doxazosin exhibited significantly higher protein binding capacities than (-)doxazosin in all the three species, and the difference in the bound concentration (Cb) between the two enantiomers was enhanced as their concentrations were increased. Although the percentage of the plasma protein binding in the dog plasma was significantly lower than that in the human plasma at 400 and 800 ng/mL, the corrected percentage of plasma protein binding was dog>human>rat.
-
SynonymsUK 33274
-
PathwayAngiogenesis
-
TargetAdrenergic Receptor
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number74191-85-8
-
Formula Weight451.5
-
Molecular FormulaC23H25N5O5
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCOc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2ccccc2O1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Grogan G, et al. An Aminocaprolactam Racemase from Ochrobactrum anthropi with Promiscuous Amino Acid Ester Racemase Activity. Chembiochem. 2018 Jun 13.
molnova catalog
related products
-
Amezinium (methylsul...
Amezinium metilsulfate has multiple mechanisms including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.
-
xanthanol
Xanthydrol is an organic chemical compound. Xanthydrol is used to test the levels of urea in the bloodstream.
-
Propranolol hydrochl...
Propranolol hydrochloride is a blocker of β1 and β2 adrenergic receptorPropranolol is a noncardioselective β-blocker.?It is reported to have membrane-stabilizing properties, but it does not own intrinsic sympathomimetic activity.?