Cart
sales@molnova.com
Doravirine
CAS No. 1338225-97-0
Doravirine ( MK-1439;MK1439 )
Catalog No. M11354 CAS No. 1338225-97-0
Doravirine (MK-1439, MK1439) is a novel, highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 12, 9.7, and 9.7 nM against WT, K103N, and Y181C reverse transcriptase (RT) mutants, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 57 | In Stock |
|
| 5MG | 88 | In Stock |
|
| 10MG | 160 | In Stock |
|
| 25MG | 318 | In Stock |
|
| 50MG | 492 | In Stock |
|
| 100MG | 710 | In Stock |
|
| 500MG | 1467 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDoravirine
-
NoteResearch use only, not for human use.
-
Brief DescriptionDoravirine (MK-1439, MK1439) is a novel, highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 12, 9.7, and 9.7 nM against WT, K103N, and Y181C reverse transcriptase (RT) mutants, respectively.
-
DescriptionDoravirine (MK-1439, MK1439) is a novel, highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 12, 9.7, and 9.7 nM against WT, K103N, and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay; shows excellent potency in suppressing the replication of WT virus with EC95 of 20 nM, as well as K103N, Y181C, and K103N/Y181C mutant viruses with EC95 of 43, 27, and 55 nM, respectively.HIV Infection Phase 3 Clinical
-
SynonymsMK-1439;MK1439
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV-1
-
Research AreaInfection
-
IndicationHIV Infection
Chemical Information
-
CAS Number1338225-97-0
-
Formula Weight425.75
-
Molecular FormulaC17H11ClF3N5O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 30 mg/mL
-
SMILESN#CC1=CC(OC2=C(C(F)(F)F)C=CN(CC(N3C)=NNC3=O)C2=O)=CC(Cl)=C1
-
Chemical NameBenzonitrile, 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lai MT, et al. Antimicrob Agents Chemother. 2014;58(3):1652-63.
2. Cté B, et al. Bioorg Med Chem Lett. 2014 Feb 1;24(3):917-22.
3. Feng M, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):590-8.
2. Cté B, et al. Bioorg Med Chem Lett. 2014 Feb 1;24(3):917-22.
3. Feng M, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):590-8.
molnova catalog
related products
-
Raltegravir
A potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM.
-
Apelin-36 (rat, mous...
Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
-
TAT 48-57
TAT (48-57) is a cell-permeable peptide, derived from HIV-1 transactivator of transcription (Tat) protein residue 48-57.This peptide is amino acid residues 48 to 57 fragment of the basic domain of HIV Tat.
