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Doramapimod
CAS No. 285983-48-4
Doramapimod( BIRB 796 | BIRB-796 | BIRB796 )
Catalog No. M13869 CAS No. 285983-48-4
A highly potent p38 MAPK inhibitor with Kd of 0.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 28 | In Stock |
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| 10MG | 45 | In Stock |
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| 25MG | 65 | In Stock |
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| 50MG | 84 | In Stock |
|
| 100MG | 116 | In Stock |
|
| 200MG | 213 | In Stock |
|
| 500MG | 358 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDoramapimod
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent p38 MAPK inhibitor with Kd of 0.1 nM.
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DescriptionA highly potent p38 MAPK inhibitor with Kd of 0.1 nM; displays no activity on ERK1, IKK2b, ZAP-70, EGFR, PKA, PKC, etc.; shows inhibition of TNFα inTHP.1 with IC50 of 18 nM; orally active.
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In Vitro——
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In Vivo——
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SynonymsBIRB 796 | BIRB-796 | BIRB796
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38α
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number285983-48-4
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Formula Weight527.6572
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Molecular FormulaC31H37N5O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=C2C=CC=CC2=C(OCCN3CCOCC3)C=C1)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
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Chemical NameUrea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pargellis C, et al. Nat Struct Biol. 2002 Apr;9(4):268-72.
2. Regan J, et al. J Med Chem. 2002 Jul 4;45(14):2994-3008.
3. Gruenbaum LM, et al. Biochem Pharmacol. 2009 Feb 1;77(3):422-32.
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