Dopamine( —— )

Catalog No. M24487 CAS No. 51-61-6

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HNMR

HPLC

MSDS

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Product Name

Dopamine
Note

Research use only, not for human use.
Brief Description

Dopamine is an inotropic vasopressor agent and dopamine receptor agonist used in neurological diseases.?
Description

Dopamine is an inotropic vasopressor agent and dopamine receptor agonist used in neurological diseases.?
In Vitro

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 μM; 24hours). Cell Proliferation Assay Cell Line:HUVECs Concentration:1 μMIncubation Time:24 hours Result:Inhibited VPF/VEGF-induced HUVEC proliferation specifically through its D2 receptor.
In Vivo

Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF. Animal Model:Syngeneic C3Heb/FeJ mice with MOT ascites tumors Dosage:50 mg/kg Administration:I.p. injection; 7 days Result:Corresponding to ~5% of the median lethal dose (LD50) in mice) beginning at 24 hours after tumor-cell injection and continuing daily for 7 days.
Synonyms

——
Pathway

GPCR/G Protein
Target

Dopamine Receptor
Recptor

dopamine
Research Area

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Indication

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1.Berke, Joshua D . What does dopamine mean?[J]. Nature Neuroscience, 2018.

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