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Digitonin

CAS No. 11024-24-1

Digitonin( Digitin | NSC 23471 | NSC 237417 )

Catalog No. M10393 CAS No. 11024-24-1

Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Digitonin
  • Note
    Research use only, not for human use.
  • Brief Description
    Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea.
  • Description
    Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea. It's aglycone is digitogenin, a spirostan steroid. It has been investigated as a detergent, as it effectively water-solubilizes lipids.
  • In Vitro
    Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro.
  • In Vivo
    In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg.
  • Synonyms
    Digitin | NSC 23471 | NSC 237417
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    11024-24-1
  • Formula Weight
    1229.34
  • Molecular Formula
    C56H92O29
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    C[C@@H]1CC[C@]2(O[C@H]3[C@H]([C@H]4[C@@H]5CC[C@H]6C[C@H]([C@@H](C[C@@]6([C@H]5CC[C@@]4([C@H]3[C@@H]2C)C)C)O)O[C@@H]7O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O[C@@H]9O[C@@H]([C@@H]([C@@H]([C@H]9O)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)O)CO)O[C@@H]%11OC[C@H]([C@@H]([C@H]%11O)O)O)O)CO)CO)O)OC1
  • Chemical Name
    beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Frenkel N, et al. J Phys Chem B. 2014 Dec 18;118(50):14632-9.
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