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Diflapolin
CAS No. 724453-98-9
Diflapolin( —— )
Catalog No. M24734 CAS No. 724453-98-9
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
|
| 10MG | 102 | In Stock |
|
| 25MG | 219 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 531 | In Stock |
|
| 500MG | 1152 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDiflapolin
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NoteResearch use only, not for human use.
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Brief DescriptionDiflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
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DescriptionDiflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
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In Vitro——
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In VivoDiflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments. Animal Model:Male CD-1 mice (zymosan-induced peritonitis mouse model)Dosage:1, 3 and 10?mg/kg Administration:I.p.; 30?min before zymosan injection Result:Induced a significant reduction of LTC4 and LTB4 peritoneal levels, starting from the dose of 1?mg/kg and comparable to the effect of MK886.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetFLAP
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RecptorsHE|FLAP
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Research Area——
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Indication——
Chemical Information
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CAS Number724453-98-9
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Formula Weight458.4
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Molecular FormulaC22H17Cl2N3O2S
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Purity>98% (HPLC)
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SolubilityDMSO:84mg/mL (183.26mM)
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SMILESO=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC3=NC4=CC=CC=C4S3)C=C2C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Garscha U, Romp E, Pace S, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017;7(1):9398. Published 2017 Aug 24. doi:10.1038/s41598-017-09795-w
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