Cart
sales@molnova.com
AZD5718
CAS No. 2041075-86-7
AZD5718( AZD-5718 | AZD 5718 )
Catalog No. M13174 CAS No. 2041075-86-7
AZD5718 (AZD-5718, AZD 5718) is a novel potent 5-lipoxygenase activating protein (FLAP) inhibitor with binding IC50 of 6.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 143 | Get Quote |
|
| 5MG | 215 | Get Quote |
|
| 10MG | 320 | Get Quote |
|
| 25MG | 531 | Get Quote |
|
| 50MG | 773 | Get Quote |
|
| 100MG | 1062 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAZD5718
-
NoteResearch use only, not for human use.
-
Brief DescriptionAZD5718 (AZD-5718, AZD 5718) is a novel potent 5-lipoxygenase activating protein (FLAP) inhibitor with binding IC50 of 6.3 nM.
-
DescriptionAZD5718 (AZD-5718, AZD 5718) is a novel potent 5-lipoxygenase activating protein (FLAP) inhibitor with binding IC50 of 6.3 nM; exhibits LTB4 inhibition in human whole blood assays with IC50 of 39 nM; reduce the production of pro-inflammatory and vasoactive leukotrienes both in vitro and in vivo.(In Vitro):Atuliflapon demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h.Atuliflapon exhibits an IC50 of 39 nM for LTB4.(In Vivo):Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively.Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood.
-
In Vitro——
-
In Vivo——
-
SynonymsAZD-5718 | AZD 5718
-
PathwayImmunology/Inflammation
-
TargetFLAP
-
RecptorFLAP
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2041075-86-7
-
Formula Weight446.511
-
Molecular FormulaC24H26N6O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (279.96 mM)
-
SMILES——
-
Chemical Name(1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexanecarboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ericsson H, et al. Clin Transl Sci. 2018 May;11(3):330-338.
2. Pettersen D, et al. J Med Chem. 2019 Mar 14. doi: 10.1021/acs.jmedchem.8b02004.
molnova catalog
related products
-
Diflapolin
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
-
AM103
AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).
-
MK-591
A potent, orally active leukotriene biosynthesis inhibitor that acts by inhibiting 5-lipoxygenase activating protein (FLAP) with IC50 of 1.6 nM in a FLAP binding assay.
