Dictamnine( Dectamine )

Catalog No. M20454 CAS No. 484-29-7

COA

Datasheet

HNMR

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Product Name

Dictamnine
Note

Research use only, not for human use.
Brief Description

Dictamnine shows anticholinesterase anti-inflammatory mutagenic and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix colon and oral carcinoma cells.
Description

Dictamnine shows anticholinesterase anti-inflammatory mutagenic and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix colon and oral carcinoma cells.
In Vitro

Western Blot Analysis Cell Line:HCT116 cells Concentration:0-100 μM Incubation Time:12 h Result:Inhibited HIF-1α (synthesis but not degradation) and Slug protein accumulation under hypoxia.
In Vivo

Animal Model:HCT116 xenograft tumor model Dosage:50 and 100 mg/kg Administration:p.o., three times a week Result:Inhibited tumor growth.Reduced HIF-1α and Slug protein level in the tumor tissue.
Synonyms

Dectamine
Pathway

Microbiology/Virology
Target

Antifection
Recptor

Antifection
Research Area

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Indication

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1.Guo N Yu L Meng R et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine[J]. Yeast 2008 25(9):631-641.

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