Diazo Biotin-PEG3-alkyne( —— )

Catalog No. M33339 CAS No. 1884349-58-9

Diazo Biotin-PEG3-alkyne is a polyethylene glycol (PEG)-based linker designed specifically for the synthesis of proteolysis-targeting chimeras (PROTACs) .

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Diazo Biotin-PEG3-alkyne
Note

Research use only, not for human use.
Brief Description

Diazo Biotin-PEG3-alkyne is a polyethylene glycol (PEG)-based linker designed specifically for the synthesis of proteolysis-targeting chimeras (PROTACs) .
Description

Diazo Biotin-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diazo Biotin-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

PROTACs
Research Area

——
Indication

——

Chemical Information

CAS Number

1884349-58-9
Formula Weight

795.95
Molecular Formula

C39H53N7O9S
Purity

>98% (HPLC)
Solubility

——
SMILES

C(CCCC(NCCOCCOCCOCCNC(=O)C1=CC=C(N=NC2=CC(CCNC(CCOCC#C)=O)=CC=C2O)C=C1)=O)[C@H]3[C@@]4([C@](CS3)(NC(=O)N4)[H])[H]
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?

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