Dendrid( 5-iodo-2′-deoxyuridine | NSC 39661 | SKF 14287 )

Catalog No. M14952 CAS No. 54-42-2

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Product Name

Dendrid
Note

Research use only, not for human use.
Brief Description

Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.
Description

Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.
In Vitro

Cell Proliferation Assay Cell Line:Crandell-Reese feline kidney (CRFK) cells Concentration:2-10 μM Incubation Time:72 hours Result:Showed the IC50 value of 4.3 μM.Cell Cytotoxicity Assay Cell Line:Crandell-Reese feline kidney (CRFK) cells Concentration:5-50 μM Incubation Time:72 hours Result:Reduced by 10.8% relatively in CRFK cells.
In Vivo

Animal Model:C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months Dosage:50-200 mg/kg Administration:Intraperitoneal injection, 3 times, 3 hours interval Result:Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.
Synonyms

5-iodo-2′-deoxyuridine | NSC 39661 | SKF 14287
Pathway

Microbiology/Virology
Target

Antifection
Recptor

Feline herpesvirus type-1(FHV-1)
Research Area

Infection
Indication

——

CAS Number

54-42-2
Formula Weight

354.1
Molecular Formula

C9H11IN2O5
Purity

>98% (HPLC)
Solubility

DMSO: 35 mg/mL (98.84 mM)
SMILES

O=C1NC(C(I)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O
Chemical Name

1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

1.Silvestri DL, et al. JAMA. 1982 Aug 27; 248(8):953-9.

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