Delavirdine

CAS No. 136817-59-9

Delavirdine ( U 90152;BHAP-U 90152 )

Catalog No. M11519 CAS No. 136817-59-9

A potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Delavirdine
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT.
  • Description
    A potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT; exhibits IC50>440 uM for DNA polymerases α and δ; blocks the replication in peripheral blood lymphocytes of 25 primary HIV-1 isolates and has low cellular cytotoxicity; retains significant activity against mutant RTs (K103N, Y181C).HIV Infection Approved
  • Synonyms
    U 90152;BHAP-U 90152
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    136817-59-9
  • Formula Weight
    456.56
  • Molecular Formula
    C22H28N6O3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C
  • Chemical Name
    Methanesulfonamide, N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dueweke TJ, et al. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.
2. Romero DL, et al. J Med Chem. 1993 May 14;36(10):1505-8.
3. Olmsted RA, et al. J Virol. 1996 Jun;70(6):3698-705.
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