Delavirdine ( U 90152;BHAP-U 90152 )

Catalog No. M11519 CAS No. 136817-59-9

A potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT.

Purity : >98% (HPLC)

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HPLC

MSDS

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Biological Information

Product Name

Delavirdine
Note

Research use only, not for human use.
Brief Description

A potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT.
Description

A potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT; exhibits IC50>440 uM for DNA polymerases α and δ; blocks the replication in peripheral blood lymphocytes of 25 primary HIV-1 isolates and has low cellular cytotoxicity; retains significant activity against mutant RTs (K103N, Y181C).HIV Infection Approved
Synonyms

U 90152;BHAP-U 90152
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

Infection
Indication

HIV Infection

Chemical Information

CAS Number

136817-59-9
Formula Weight

456.56
Molecular Formula

C22H28N6O3S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C
Chemical Name

Methanesulfonamide, N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Dueweke TJ, et al. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.
2. Romero DL, et al. J Med Chem. 1993 May 14;36(10):1505-8.
3. Olmsted RA, et al. J Virol. 1996 Jun;70(6):3698-705.

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