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Home - Products - Antibody Drug Conjugates (ADC) - ADC Cytotoxin - PNU-159682

PNU-159682

CAS No. 202350-68-3

PNU-159682 ( PNU159682;PNU 159682 )

Catalog No. M13151 CAS No. 202350-68-3

A highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity; a topoisomerase inhibitor and ADCs cytotoxin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PNU-159682
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity; a topoisomerase inhibitor and ADCs cytotoxin.
  • Description
    A highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity; a topoisomerase inhibitor and ADCs cytotoxin.
  • Synonyms
    PNU159682;PNU 159682
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADC Cytotoxin
  • Recptor
    ADC Cytotoxin
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    202350-68-3
  • Formula Weight
    641.62
  • Molecular Formula
    C32H35NO13
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=C(C2=C(C(O)=C1C3)C[C@@](O)(C(CO)=O)C[C@@H]2O[C@@H]4O[C@H]([C@H]5O[C@@H]6[C@@H](OC)OCCN6[C@H]5C4)C)O)C7=C3C=CC=C7OC
  • Chemical Name
    5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-, (8S,10S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Quintieri L, et al. Clin Cancer Res. 2005 Feb 15;11(4):1608-17.
2. Yu SF, et al. Clin Cancer Res. 2015 Jul 15;21(14):3298-306.
3. Mazzini S, et al. Bioorg Med Chem. 2012 Dec 15;20(24):6979-88.
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