Darunavir

CAS No. 206361-99-1

Darunavir( TMC-114 | UIC-94017 )

Catalog No. M13207 CAS No. 206361-99-1

A potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Darunavir
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM.
  • Description
    A potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM; blockes the infectivity and replication of HIV-1(NL4-3) variants with IC50 of 3-29 nM, also potent against multi-PI-resistant clinical HIV-1 variants isolated from patients; used to treat and prevent HIV/AIDS.HIV Infection Approved(In Vitro):Darunavir (TMC114, 1a) has a stability comparable to other protease inhibitors.Darunavir (TMC114, UIC-94017) blocks the infectivity and replication of each of HIV-1NL4-3 variants exposed to and selected for resistance to Ro 31-8959, MK-639, AG1341, or ABT 538 at concentrations up to 5 μM (IC50s, 0.003 to 0.029 μM), although it was less active against HIV-1NL4-3 variants selected for resistance to VX-478 (IC50, 0.22 μM).
  • In Vitro
    Darunavir (TMC114, 1a) has a stability comparable to other protease inhibitors.Darunavir (TMC114, UIC-94017) blocks the infectivity and replication of each of HIV-1NL4-3 variants exposed to and selected for resistance to Ro 31-8959, MK-639, AG1341, or ABT 538 at concentrations up to 5 μM (IC50s, 0.003 to 0.029 μM), although it was less active against HIV-1NL4-3 variants selected for resistance to VX-478 (IC50, 0.22 μM).
  • In Vivo
    ——
  • Synonyms
    TMC-114 | UIC-94017
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIVProtease
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    206361-99-1
  • Formula Weight
    547.6636
  • Molecular Formula
    C27H37N3O7S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N
  • Chemical Name
    Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Surleraux DL, et al. J Med Chem. 2005 Mar 24;48(6):1813-22. 2. Koh Y, et al. Antimicrob Agents Chemother. 2003 Oct;47(10):3123-9. 3. King NM, et al. J Virol. 2004 Nov;78(21):12012-21.
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