Dagrocorat

CAS No. 1044535-52-5

Dagrocorat( PF 00251802 )

Catalog No. M10219 CAS No. 1044535-52-5

Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 896 Get Quote
50MG 2142 Get Quote
100MG 2790 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Dagrocorat
  • Note
    Research use only, not for human use.
  • Brief Description
    Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.
  • Description
    Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.Rheumatoid Arthritis Phase 1 Discontinued.
  • In Vitro
    Dagrocorat is metabolized by cytochrome P450 (CYP)3A to an N-oxide metabolite. Dagrocorat is a reversible inhibitor of several CYPs, such as CYP3A and CYP2D6.
  • In Vivo
    ——
  • Synonyms
    PF 00251802
  • Pathway
    Endocrinology/Hormones
  • Target
    GR
  • Recptor
    GR
  • Research Area
    Inflammation/Immunology
  • Indication
    Rheumatoid Arthritis

Chemical Information

  • CAS Number
    1044535-52-5
  • Formula Weight
    494.558
  • Molecular Formula
    C29H29F3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (505.51 mM)
  • SMILES
    FC([C@]1(O)CC[C@]2(CC3=CC=CC=C3)C4=CC=C(C(NC5=CC=CN=C5C)=O)C=C4CC[C@]2([H])C1)(F)F
  • Chemical Name
    (4bR,7S,8aR)-4b-benzyl-7-hydroxy-N-(2-methylpyridin-3-yl)-7-(trifluoromethyl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ripp SL, et al. Clin Pharmacol Drug Dev. 2017 Nov 7. doi: 10.1002/cpdd.411.
molnova catalog
related products
  • Exicorilant

    Exicorilant (CORT125281, CORT-125281) is a potent, selective glucocorticoid receptor (GR) antagonist.

  • ZK-216348

    ZK-216348 is a potent, selective, dissociated glucocorticoid receptor agonist with pIC50 of 7.7.

  • Cortisone acetate

    Cortisone acetate (Cortisone 21-acetate) is a synthetic glucocorticoid corticosteroid and corticosteroid ester.