
Dagrocorat
CAS No. 1044535-52-5
Dagrocorat( PF 00251802 )
Catalog No. M10219 CAS No. 1044535-52-5
Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 896 | Get Quote |
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50MG | 2142 | Get Quote |
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100MG | 2790 | Get Quote |
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200MG | Get Quote | Get Quote |
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Biological Information
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Product NameDagrocorat
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NoteResearch use only, not for human use.
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Brief DescriptionDagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.
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DescriptionDagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.Rheumatoid Arthritis Phase 1 Discontinued.
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In VitroDagrocorat is metabolized by cytochrome P450 (CYP)3A to an N-oxide metabolite. Dagrocorat is a reversible inhibitor of several CYPs, such as CYP3A and CYP2D6.
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In Vivo——
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SynonymsPF 00251802
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PathwayEndocrinology/Hormones
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TargetGR
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RecptorGR
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Research AreaInflammation/Immunology
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IndicationRheumatoid Arthritis
Chemical Information
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CAS Number1044535-52-5
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Formula Weight494.558
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Molecular FormulaC29H29F3N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (505.51 mM)
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SMILESFC([C@]1(O)CC[C@]2(CC3=CC=CC=C3)C4=CC=C(C(NC5=CC=CN=C5C)=O)C=C4CC[C@]2([H])C1)(F)F
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Chemical Name(4bR,7S,8aR)-4b-benzyl-7-hydroxy-N-(2-methylpyridin-3-yl)-7-(trifluoromethyl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ripp SL, et al. Clin Pharmacol Drug Dev. 2017 Nov 7. doi: 10.1002/cpdd.411.
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