Dagrocorat( PF 00251802 )

Catalog No. M10219 CAS No. 1044535-52-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Dagrocorat
Note

Research use only, not for human use.
Brief Description

Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.
Description

Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor.Rheumatoid Arthritis Phase 1 Discontinued.
In Vitro

Dagrocorat is metabolized by cytochrome P450 (CYP)3A to an N-oxide metabolite. Dagrocorat is a reversible inhibitor of several CYPs, such as CYP3A and CYP2D6.
In Vivo

——
Synonyms

PF 00251802
Pathway

Endocrinology/Hormones
Target

GR
Recptor

GR
Research Area

Inflammation/Immunology
Indication

Rheumatoid Arthritis

CAS Number

1044535-52-5
Formula Weight

494.558
Molecular Formula

C29H29F3N2O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (505.51 mM)
SMILES

FC([C@]1(O)CC[C@]2(CC3=CC=CC=C3)C4=CC=C(C(NC5=CC=CN=C5C)=O)C=C4CC[C@]2([H])C1)(F)F
Chemical Name

(4bR,7S,8aR)-4b-benzyl-7-hydroxy-N-(2-methylpyridin-3-yl)-7-(trifluoromethyl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide

1. Ripp SL, et al. Clin Pharmacol Drug Dev. 2017 Nov 7. doi: 10.1002/cpdd.411.

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