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Home - Products - Proteasome/Ubiquitin - E3 Ubiquitin Ligase - DT204

DT204

CAS No. 428497-71-6

DT204( DT-204 | DT 204 )

Catalog No. M14453 CAS No. 428497-71-6

DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    DT204
  • Note
    Research use only, not for human use.
  • Brief Description
    DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis.
  • Description
    DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis; stablizes and increases p27 levels, does not increase the level of p53, demonstrates potential synergy with CI values of 0.7, 0.8 and 0.7 for RPMI8226, U266 and MM1.S respectively combined with 1 nM BTZ, co-treatment induces apoptosis in cells resistant to the proteasome inhibitors BTZ, carfilzomib or ixazomib; overcomes drug resistance and reduces the in vivo growth of myeloma tumors in murine models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DT-204 | DT 204
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    428497-71-6
  • Formula Weight
    482.729
  • Molecular Formula
    C19H13BrClNO5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)COC1=CC=C(Br)C=C1/C=C(SC(N2CC3=CC=C(Cl)C=C3)=O)/C2=O
  • Chemical Name
    2-(4-bromo-2-((3-(4-chlorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Malek E, et al. Leukemia. 2017 Mar;31(3):645-653.
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