DSRM-3716 ( 5-Iodoisoquinoline )

Catalog No. M28581 CAS No. 58142-99-7

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Product Name

DSRM-3716
Note

Research use only, not for human use.
Brief Description

Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
Description

Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.(In Vitro):Treatment with the isoquinoline Isoquinoline, 5-iodo- (9CI) produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. Isoquinoline, 5-iodo- (9CI) prevented NfL release from severed axons in a dose-dependent manner.
Synonyms

5-Iodoisoquinoline
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

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Research Area

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Indication

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1.Suzuki; Kowata; Kurosawa[Bulletin of the Chemical Society of Japan, 1980, vol. 53, # 7, p. 2099 - 2100]

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