DS86760016 ( DS 86760016 )

Catalog No. M12864 CAS No. 1853176-89-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DS86760016
Note

Research use only, not for human use.
Brief Description

DS86760016 is a novel selective bacterial leucyl-tRNA synthetase (LeuRS) inhibitor with IC50 of 0.38 uM (Escherichia coli, LeuRS).
Description

DS86760016 is a novel selective bacterial leucyl-tRNA synthetase (LeuRS) inhibitor with IC50 of 0.38 uM (Escherichia coli, LeuRS); inhibits Pseudomonas aeruginosa and Acinetobacter baumannii with IC50 of 0.62 and 0.16 uM, respectively; shows active against MDR Gram-negative bacteria (MIC 0.25-2 ug/mL) with an improved pharmacokinetic profile compared with GSK2251052; also shows lower mutant prevention concentrations against P. aeruginosa compared to GSK2251052.
Synonyms

DS 86760016
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1853176-89-2
Formula Weight

243.45
Molecular Formula

C9H11BClNO4
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

(S)-3-(aminomethyl)-[1,3]dioxolo[4',5':5,6]benzo[1,2-c][1,2]oxaborol-1(3H)-ol hydrochloride

1. Purnapatre KP, et al. Antimicrob Agents Chemother. 2018 Feb 5. pii: AAC.01987-17.

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