DS-1205 ( —— )

Catalog No. M28589 CAS No. 1855860-24-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DS-1205
Note

Research use only, not for human use.
Brief Description

DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo.
Description

DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo.(In Vitro):DS-1205 (0.3-33 μM; 2-24 h) inhibits hGAS6-induced migration in NIH3T3-AXL cells (EC50=2.7 nM). DS-1205 (1-10000 μM; 2-24 h) significantly inhibits the phosphorylation of AXL in NIH3T3-AXL cells. DS-1205 decreases NIH3T3 cell proliferation but not obviously inhibits growth (GI50>10,000 nM).(In Vivo):DS-1205 (3.1-50 mg/kg; p.o. bid for 5 d) exhibits pAXL inhibition mediated antitumor effects in mice.
Synonyms

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Pathway

Tyrosine Kinase
Target

TAM Receptor
Recptor

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Research Area

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Indication

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1.Allmann TC, et al. Synthesis of Hydroxypyrrolone Carboxamides Employing Selectfluor. Chemistry. 2016 Jan 4;22(1):111-5.

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