DRAinh-A250( DRAinhA250 | DRAinh A250 | DRAinh-A250 )

Catalog No. M16225 CAS No. 858747-13-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DRAinh-A250
Note

Research use only, not for human use.
Brief Description

DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA).
Description

DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM; does not inhibit the homologous anion exchangers SLC26A4 (pendrin) or SLC26A6 (PAT-1), as well as other related proteins or intestinal ion channels; blocked fluid absorption in closed colonic loops but not in jejunal loops in mice, while the NHE3 (SLC9A3) inhibitor tenapanor blocked absorption only in the jejunum; reduces signs of constipation in loperamide-treated mice after oral treatment.
In Vitro

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In Vivo

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Synonyms

DRAinhA250 | DRAinh A250 | DRAinh-A250
Pathway

Membrane Transporter/Ion Channel
Target

Chloride Channel
Recptor

Chloride Channel
Research Area

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Indication

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CAS Number

858747-13-4
Formula Weight

417.255
Molecular Formula

C20H17BrO5
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(O)CC(C1=O)=C(C)C2=C(O1)C(C)=C(OCC3=CC=CC(Br)=C3)C=C2
Chemical Name

2-(7-((3-bromobenzyl)oxy)-4,8-dimethyl-2-oxo-2H-chromen-3-yl)acetic acid

1. Haggie PM, et al. JCI Insight. 2018 Jul 26;3(14). pii: 121370.

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