DPC-681 ( DPH-153893 )

Catalog No. M13867 CAS No. 284661-68-3

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Product Name

DPC-681
Note

Research use only, not for human use.
Brief Description

A potent and selective inhibitor of HIV-1 protease with IC90 of 4-40 nM.
Description

A potent and selective inhibitor of HIV-1 protease with IC90 of 4-40 nM; showes no loss in potency towardrecombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions.
Synonyms

DPH-153893
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

Infection
Indication

——

CAS Number

284661-68-3
Formula Weight

669.85
Molecular Formula

C35H48FN5O5S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC(C)(C)[C@@H](C(N)=O)N(C(CNCC1=CC=CC(F)=C1)=O)[C@@H](CC2=CC=CC=C2)[C@H](O)CN(S(=O)(C3=CC=CC(N)=C3)=O)CC(C)C
Chemical Name

L-Valinamide, N-[(3-fluorophenyl)methyl]glycyl-N-[(1S,2R)-3-[[(3-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-3-methyl-

1. Kaltenbach RF 3rd, et al. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8.
2. Solon EG, et al. Drug Metab Dispos. 2002 Nov;30(11):1164-9.

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