DORA-22

Research use only, not for human use.

DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryDORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory.

DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryDORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory.DORA-22 treatment improved the insomnia-related sleep disruption-wake was attenuated and NREM sleep was normalized.?REM sleep amounts were enhanced compared with vehicle treatment for one dose (30 mg/kg).?In the first hour of insomnia model exposure, DORA-22 promoted the number and average duration of NREM sleep spindles, which have been previously proposed to play a role in memory consolidation (all doses).?Water maze measures revealed probe trial performance improvement for select doses of DORA-22, including increased time spent in the platform quadrant (10 and 30 mg/kg) and time spent in platform location and number of platform crossings (10 mg/kg only).?In conclusion, DORA-22 treatment improved insomnia-related sleep disruption and memory consolidation deficits.

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Others

Other Targets

OX Receptor

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1088991-95-0

424.4

C23H22F2N4O2?

>98% (HPLC)

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C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(F)ccc1-c1ncccn1

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(-20℃)

With Ice Pack

≥ 2 years