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DK419
CAS No. 2102672-22-8
DK419( —— )
Catalog No. M26671 CAS No. 2102672-22-8
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 10MG | 410 | Get Quote |
|
| 25MG | 678 | Get Quote |
|
| 50MG | 954 | Get Quote |
|
| 100MG | 1287 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameDK419
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NoteResearch use only, not for human use.
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Brief DescriptionDK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.
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DescriptionDK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.(In Vitro):DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally.(In Vivo):DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorLDL| UGT1A1
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Research Area——
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Indication——
Chemical Information
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CAS Number2102672-22-8
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Formula Weight407.7
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Molecular FormulaC16H8ClF6N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (204.39 mM)
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SMILESFC(F)(F)c1nc2cc(Cl)cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c2[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ngoc TM, et al. Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica. Biosci Biotechnol Biochem. 2008 Aug;72(8):2158-63.
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