
DIM-C-pPhOH
CAS No. 151358-47-3
DIM-C-pPhOH( DIM-C-pPhOH )
Catalog No. M18059 CAS No. 151358-47-3
Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 33 | In Stock |
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5MG | 53 | In Stock |
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10MG | 68 | In Stock |
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25MG | 140 | In Stock |
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50MG | 215 | In Stock |
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100MG | 356 | In Stock |
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200MG | 469 | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameDIM-C-pPhOH
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NoteResearch use only, not for human use.
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Brief DescriptionNur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines.
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DescriptionDIM-C-pPhOH is a Nur77 Antagonist. DIM-C-pPhOH inhibits lung cancer cell and tumor growth in a metastasis model.(In Vitro):DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines.(In Vivo):DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.
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In VitroDIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines. Cell Proliferation Assay Cell Line:ACHN and 786-O cells Concentration:7.5 μM, 15 μM, 20 μM Incubation Time:24 hours Result:Significantly decreased cell proliferation.Apoptosis Analysis Cell Line:ACHN and 786-O cells Concentration:20 μM Incubation Time:24 hours Result:Induced apoptosis in ACHN and 786-O cells.Western Blot Analysis Cell Line:ACHN and 786-O cells Concentration:15 μM, 20 μM Incubation Time:24 hours Result:Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases.
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In VivoDIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth. Animal Model:Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells Dosage:30 mg/kg/day Administration:Oral gavage; daily; for 50 days Result:Resulted in a significant inhibition of tumor growth.
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SynonymsDIM-C-pPhOH
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PathwayOthers
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TargetAntioxidant
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RecptorNur77
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Research Area——
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Indication——
Chemical Information
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CAS Number151358-47-3
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Formula Weight338.41
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Molecular FormulaC23H18N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (369.39 mM)
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SMILESOc1ccc(cc1)C(c3cnc2ccccc23)c5cnc4ccccc45
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Chemical Name1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chintharlapalli S,etal.Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.J Biol Chem. 2005 Jul 1;280(26):24903-14.
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