DIM-C-pPhOH

CAS No. 151358-47-3

DIM-C-pPhOH( DIM-C-pPhOH )

Catalog No. M18059 CAS No. 151358-47-3

Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 33 In Stock
5MG 53 In Stock
10MG 68 In Stock
25MG 140 In Stock
50MG 215 In Stock
100MG 356 In Stock
200MG 469 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    DIM-C-pPhOH
  • Note
    Research use only, not for human use.
  • Brief Description
    Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines.
  • Description
    DIM-C-pPhOH is a Nur77 Antagonist. DIM-C-pPhOH inhibits lung cancer cell and tumor growth in a metastasis model.(In Vitro):DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines.(In Vivo):DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.
  • In Vitro
    DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines. Cell Proliferation Assay Cell Line:ACHN and 786-O cells Concentration:7.5 μM, 15 μM, 20 μM Incubation Time:24 hours Result:Significantly decreased cell proliferation.Apoptosis Analysis Cell Line:ACHN and 786-O cells Concentration:20 μM Incubation Time:24 hours Result:Induced apoptosis in ACHN and 786-O cells.Western Blot Analysis Cell Line:ACHN and 786-O cells Concentration:15 μM, 20 μM Incubation Time:24 hours Result:Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases.
  • In Vivo
    DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth. Animal Model:Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells Dosage:30 mg/kg/day Administration:Oral gavage; daily; for 50 days Result:Resulted in a significant inhibition of tumor growth.
  • Synonyms
    DIM-C-pPhOH
  • Pathway
    Others
  • Target
    Antioxidant
  • Recptor
    Nur77
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    151358-47-3
  • Formula Weight
    338.41
  • Molecular Formula
    C23H18N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (369.39 mM)
  • SMILES
    Oc1ccc(cc1)C(c3cnc2ccccc23)c5cnc4ccccc45
  • Chemical Name
    1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chintharlapalli S,etal.Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.J Biol Chem. 2005 Jul 1;280(26):24903-14.
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