DI-591

Research use only, not for human use.

DI-591 (DI591)?is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2.

DI-591 (DI591)?is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2; displays no affinity against DCN3/4/5 (Ki>10 uM); selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members; accumulates NRF2 protein and its transcriptional activation in cells.

Western Blot Analysis Cell Line:KYSE70 cells Concentration:0 μM, 1 μM, 3 Μm or 10 μM Incubation Time:1 hour Result:Potently bound to cellular DCN1 and DCN2 proteins. Enhanced the stability of DCN1 and DCN2 protein in a dose-dependent manner.RT-PCRCell Line:THLE2 cells Concentration:10 μM Incubation Time:24 hours Result:Robustly increases the mRNA levels of NQO1 and HO1.

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DI591

Proteasome/Ubiquitin

E2

E2

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2245887-38-9

585.808

C31H47N5O4S

>98% (HPLC)

10 mM in DMSO

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(S)-N-((S)-1-cyclohexyl-2-(3-morpholinopropanamido)ethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide

(-20℃)

With Ice Pack

≥ 2 years