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DHODH-IN-14
CAS No. 1364791-93-4
DHODH-IN-14 ( —— )
Catalog No. M26155 CAS No. 1364791-93-4
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.
Purity : >98% (HPLC)
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Size | Price / USD | Stock | Quantity |
2MG | 264 | Get Quote |
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5MG | 404 | Get Quote |
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10MG | 593 | Get Quote |
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25MG | 888 | Get Quote |
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50MG | 1251 | Get Quote |
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100MG | 1692 | Get Quote |
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500MG | 3402 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameDHODH-IN-14
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NoteResearch use only, not for human use.
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Brief DescriptionDHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.
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DescriptionDHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.(In Vitro):DHODH-IN-14 is a hydroxyfuran analog of A771726, which contains a biphenyl scaffold with a fluorine substituent. Turning to the derivative DHODH-IN-14, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, it was found that DHODH-IN-14 was bound in a BQN-like manner, that is, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. Although it was not found on 1D3G and 1UUO that hydroxyfuran interacted with Tyr356 in a similar way to leflunomide, when 2BXV was used as a docking target, a large portion of such postures were found.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorE3 Ligase Ligand-Linker Conjugate
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Research Area——
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Indication——
Chemical Information
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CAS Number1364791-93-4
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Formula Weight353.2
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Molecular FormulaC15H7F4N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESFc1c(F)c(-c2ccccc2)c(F)c(F)c1NC(=O)c1no[nH]c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
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